GSEA using the MSigDB database demonstrated that the GJB2, PAQR5 and CLEC12A genes activate inflammatory-related signaling (NES > 0) and suppress the cholesterol homeostasis (NES < 0), revealing their role in the meniscal degradation process during osteoarthritis progression (Figure 5 and Tables S5–S7). This evidence concerns the gene PAQR5 and osteoarthritis.