Key genes involved in oxidative phosphorylation, including ATP5A1, ATP5B, and ATP5J, and numerous ribosomal protein genes (e.g., RPS20, RPL31), demonstrated consistent downregulation in sepsis samples, supporting the notion of translational and metabolic suppression as a response to acute systemic inflammation [22,46,47,48,49,50]. The gene discussed is ATP5F1B; the disease is Sepsis.