Treatment with an RONS scavenger, a SIRT1 activator, and an inhibitor of mitochondrial fission relieved allodynia and decreased the increase in CGRP, mitogen-activated protein kinase 1 (ERK), and glutamate receptor ionotropic, NMDA 2B (NMDAR2B) phosphorylation, which are crucial in migraine pathogenesis [103,104,105]. This evidence concerns the gene SIRT1 and migraine disorder.