Additionally, the kinases p38 mitogen-activated protein kinase (p38 MAPK) and AMP-activated protein kinase (AMPK) might be involved in the cell phosphorylation in different pathological residues related to the progression of AD and indirectly contribute to the conformational changes of tau that favor microtubule instability, expose the hydrophobic domains, and facilitate the formation of neurotoxic oligomers [36,37,38,39]. Here, MAPT is linked to Alzheimer disease.