DOM3Z gene product has a role in pre-mRNA quality control and has been connected with the autoimmune disease, Systemic Lupus Erythematosus [45] Thus, the differential methylation of the twelve gene promoters affects genes that have functions that are related directly or indirectly related to immune functions, a key feature of the pathophysiology of the LC and ME/CFS conditions. Here, DXO is linked to systemic lupus erythematosus.