We previously showed that in a modified swim test model of adverse contextual learning, a two-week thiamine pre-treatment of C57BL/6 mice at a dose of 200 mg/kg/day alleviated depressive-like and anxiety-like behaviors, reduced blood corticosterone levels, decreased brain MDA levels, and normalized elevated brain Il-1β, Tnf, Cox-1, and Gsk-3β expression, which was induced by stress [43,45,47]. The gene discussed is TNF; the disease is Anxiety.