CDKL5 and memory impairment: Since the constitutive loss of Cdkl5 in Cdkl5 KO mice has been associated with a broad range of behavioral impairments, including deficits in motor coordination, autistic-like traits, reduced social interactions, and memory impairments [42,43,68,69,70], we assessed these same behavioral domains in the Cdkl5flox/Y(Cre+) cKO mouse model.