CDKL5 and craniodiaphyseal dysplasia: Previous studies in constitutive Cdkl5 KO mouse models have highlighted the importance of CDKL5 during early developmental stages, with animals displaying profound synaptic deficits, impaired neuronal maturation, and a wide spectrum of behavioral abnormalities that resemble core features of CDD [42,43,45,48,50,54,55,56,57].