Defects in the CFTR protein synthesis and malfunction of the CFTR protein lead to a common monogenic autosomal recessive disorder, cystic fibrosis (CF), and CFTR-related disorders such as congenital bilateral aplasia of the vas deferens (CBAVD), bronchiectasis, and chronic pancreatitis. This evidence concerns the gene CFTR and congenital bilateral aplasia of vas deferens from CFTR mutation.