The most common genetic causes of male infertility and subfertility include chromosomal aberrations [2,3], Y-chromosome microdeletions [3,4], mutations and polymorphisms of the androgen receptor gene AR [5], mutations of genes associated with congenital hypogonadotropic hypogonadism and Kallmann syndrome [6,7], and pathogenic variants of the transmembrane conductance regulator gene (CFTR) [8,9,10]. Here, CFTR is linked to male infertility.