The rs3087404/SMUG1 SNP has been linked to various diseases, including an increased risk of cervical intraepithelial neoplasia III (CIN III) [37] and cervical squamous cell carcinoma (CSCC) in HR-HPV-positive individuals [38], as well as a potential role in the development of age-related macular degeneration (AMD) [39] and the onset and recurrence of depressive disorder [40]. Here, SMUG1 is linked to age-related macular degeneration.