Figure 5B presents a focused view of these hub genes, among which NOTCH1, KAT2A, DNMT1, and KMT2D showed the highest scores. These genes may play crucial roles in PIEZO1-related signaling pathways and could contribute to the molecular mechanisms underlying ccRCC progression, warranting further functional characterization. This evidence concerns the gene PIEZO1 and nonpapillary renal cell carcinoma.