Supporting this concept, our functional enrichment analyses of genes positively correlated with PIEZO1 revealed strong associations with transcriptional regulatory pathways, particularly those linked to Notch signaling, such as “NOTCH1 Intracellular Domain Regulates Transcription” and “Signaling by NOTCH1 in Cancer.” Key hub genes in the associated protein interaction network included NOTCH1, KMT2D, and DNMT1, suggesting that PIEZO1 may influence epigenetic programming and tumor cell plasticity. This evidence concerns the gene NOTCH1 and cancer.