PIEZO1 and neoplasm: PIEZO1 has been implicated in the regulation of tumor cell proliferation through activation of the PI3K/AKT/mTOR signaling pathway, promotion of angiogenesis via HIF-1α upregulation, and facilitation of processes such as migration, invasion, metastasis, and epithelial–mesenchymal transition (EMT), while also reducing apoptosis [27,28].