Moreover, white adipose tissue secretes hormones, such as adiponectin, leptin, and resistin, and cytokines such as tumor necrosis factor-alpha (TNF-α), IL-6, and monocyte chemotactic protein-1, which regulate glucose metabolism, insulin sensitivity, tissue repair, and low-grade systemic inflammation related to obesity [11,12,13,14,15]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.