Of note, Clpp (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit), a mitochondrial protease involved in protein quality control, regulates mitochondrial proteostasis relevant to cardiomyopathy, and its downregulation has been demonstrated to mitigate cardiomyopathic features in preclinical models [43]. Here, CLPP is linked to cardiomyopathy.