SLC7A11 and cancer: Of note, xc_system/SLC7A11 is frequently upregulated in cancer cells, enabling survival under stressful conditions and in ferroptosis [179]; inhibitors of the xc_system, like erastin and analogs (sulfasalazine, sorafenib), by interfering with x-CT function, provoke ferroptosis in most cancer cells [3,8] and thwart tumor growth [180] and in vivo data showed that increased SLC7A11 fosters primary tumor growth but suppresses tumor metastasis [179].