Accordingly, cells harboring constructs miming GPX4 dephosphorylation at serine 2 showed a decreased GPX4/p53 interaction and were more prone to ferroptosis; other data in vivo using xenograft tumor models, showed that overexpressing PP2AB55β-tumors had reduced growth and were more sensitive to sorafenib [201]. Here, GPX4 is linked to neoplasm.