Another study in glioblastoma revealed that p53 indirectly promotes ALOXE3 activity through negative regulation of SLC7A11; ALOXE3 deficiency (caused by miR-18a) renders glioblastoma cells resistant to p53/SLC7A11-mediated ferroptosis, hence facilitating their growth in orthotopic models [203]. This evidence concerns the gene TP53 and glioblastoma.