Therefore, according to the significant role played by p53 in the regulation of the SLC7A11/ GSH/GPX4 axis, these ncRNAs may be classified as p53 agonists or antagonists based on their ability to promote or inhibit ferroptosis in cancer cells, thus demonstrating a strong and complex interplay of p53 and ncRNAs in the regulatory mechanisms of antioxidant defense systems [307,308]. This evidence concerns the gene TP53 and cancer.