Polymorphisms:GSTO1*A140D (C419A; rs4925), polymorphisms of other GSTs (GSTT1, GSTM1, GSTP1), and CYP1A1Main findings: - no significant difference in the frequency of the GSTO1*A140D polymorphism between patients with benign prostatic hyperplasia and those with prostate cancer;- no association of GSTO1*A140D polymorphism with parameters of aggressiveness or response to radiotherapy in prostate cancer patients. The gene discussed is HPGDS; the disease is prostate cancer.