Polymorphisms: GSTO1*A140D (C419A; rs4925), GSTO2*N142D (A424G; rs156697)Main findings: - increased ALL risk in with heterozygous GSTO1*A140D variant;- significant association between GSTO2*N142D polymorphism and high-risk group of ALL. The gene discussed is GSTO1; the disease is acute lymphoblastic leukemia.