Polymorphisms: GSTO1*A140D (C419A; rs4925), GSTO2*N142D (A424G; rs156697), and polymorphisms of other GSTs (GSTM1, GSTT1, GSTP1)Main findings:- no association between GSTO1*A140D (allele or genotype frequencies) and B-ALL risk;- increased cancer risk in subjects with variant G allele (D140) and for heterozygous GSTO2-AG (N/D) and homozygous GSTO2-GG (D/D) variant genotypes;- significant association between GSTO1*C/GSTO2*G haplotype and B-ALL risk;- significantly lower DFS in subjects with GSTO2*GG (D/D) genotype. The gene discussed is GSTO2; the disease is cancer.