Polymorphisms: GSTO1: rs2282326; GSTO2: rs17116779, rs156699, rs7085725, rs157077 (C20T); other GSTs (GSTA1, GSTA4, GSTM2, GSTM3, and GSTP1)Main findings:- increased risk of death and a shorter median survival time in subjects carrying at least one variant allele of GSTO2 rs7085725;- increased risk of death in subjects with both GSTO2 rs7085725 and GSTP1 rs4147581 genotypes;- GSTO2 and GSTP1 gene polymorphisms may serve as independent prognostic markers for HCC. Here, HPGDS is linked to hepatocellular carcinoma.