Polymorphisms:GSTO1*A140D (C419A; rs4925), GSTO2*N142D (A424G; rs156697), GSTO2 polymorphism in 5′UTR gene region (A183G; rs2297235)Main findings:- increased ccRCC risk in subjects with combined homozygous GSTO1*A140D (D/D) and GSTO2*N142D (D/D) variants;- increased risk of ccRCC in subjects with GSTO1*A (rs4925), GSTO2*G (rs156697), and GSTO2*G (rs2297235) haplotype (H2) compared to haplotype including all three referent alleles (H1);- increased risk of ccRCC in smokers with homozygous GSTO2*N142D (rs156697) variant. This evidence concerns the gene GSTO2 and nonpapillary renal cell carcinoma.