Radic et al. [94] investigated the impact of specific genetic variants—GSTO1*A140D (C419A; rs4925), GSTO2*N142D (A424G; rs156697), and the GSTO2 polymorphism in the 5′UTR gene region (A183G; rs2297235)—on the risk of developing the most aggressive renal cell carcinoma (RCC) subtype, the clear cell RCC (ccRCC). This evidence concerns the gene GSTO2 and hereditary clear cell renal cell carcinoma.