On the other hand, a large study on patients with pathologically confirmed primary lung cancer, including both small cell and non-small cell lung cancer, and investigating 290 SNPs in the glutathione pathway did not find any significant association between different GSTO1-1 (rs2164624; rs4925) or GSTO2-2 (rs156697) polymorphisms and survival upon cisplatin chemotherapy [88]. This evidence concerns the gene GSTO2 and lung cancer.