At first, the top 10 mRNA genes from the MCFS-ID ranking (ADAMTS5, COL10A1, TMEM220, ARHGAP20, MMP11, CAVIN2, PLPP3, MICU3, MME, CD300LG) were screened, and all of them were confirmed to have an association to cancer prediction and development. Here, TMEM220 is linked to cancer.