Genes encoding TFs that bind to motifs identified in sequences containing hyper-methylated cytosines (Figure 5D) belonged to, among others, cell cycle-signaling pathways, transcription misregulation in cancer, the TGF-β pathway, cellular senescence, and several cancer types, including breast cancer q-value = 0.0000234 (Figure 5D and Table S10). This evidence concerns the gene TGFB1 and breast carcinoma.