TGFB1 and cancer: Next, using the KEGG database [67] (Figure 5D), it was verified that the majority of biological pathways related to genes encoding TF motifs overlapping hyper-methylated DMS were precisely connected with cancer (e.g., misregulation in cancer, breast cancer, lung cancer, etc.)as well as through pathways, which are well-known to be connected with tumorigenesis (e.g., TGF-β signaling pathway [68], human cytomegalovirus infection [69]).