There is a number of scientific research for each of the top 10 mRNA genes, well-documenting their significance and association with cancerogenesis: ADAMTS5 [43], TMEM220 [44], ARHGAP20 [45], MICU3 [46]; or precisely with breast cancer: COL10A1 [47], MMP11 [48], CAVIN2 (formerly known as SDPR) [49], PLPP3 [50], MME [51], and CD300LG [52]. This evidence concerns the gene COL10A1 and breast cancer.