DICER dysregulation is associated with the duration of antiretroviral use and, interestingly, correlates with alterations in circulating miRNAs from small extracellular vesicles (enhanced miR-20a-3p and depleted miR-186 and miR-324-5p), which could also contribute to acquired lipodystrophy and associated metabolic and inflammatory perturbations in PLWH [53]. The gene discussed is DICER1; the disease is lipodystrophy.