GLP1R and obesity due to melanocortin 4 receptor deficiency: For the prolonged management of obesity, GLP-1 receptor agonists (GLP-1 RAs), such as Semaglutide (Wegovy®) or Liraglutide (Saxenda®), in addition to Orlistat, phentermine/topiramate, and naltrexone/bupropion, should be prescribed [12].