MMP2 and keratoacanthoma: The mean level of MMP-2 was significantly higher in actinic keratosis lesions compared to keratoacanthoma (124.46 vs. 94.58 RFU/mg protein; p = 0.001) or Bowen’s disease lesions (124.46 vs. 76.0 RFU/mg protein; p = 0.001) (Table 2, Figure 1).