The mean level of MMP-2 was significantly lower in cases with Bowen’s disease than in cases with keratoacanthoma, both in cases with moderate dysplasia (SC keratoacanthoma-like, moderately differentiated/SCC in situ) (100.0 vs. 79.5 RFU /mg protein; p = 0.001) and in cases with moderate–severe dysplasia (SC keratoacanthoma-like, with severe atypia/high-grade SIL) (89.17 vs. 72.5 RFU/mg protein; p = 0.001) (Table 2, Figure 2). This evidence concerns the gene MMP2 and keratoacanthoma.