The mean level of MMP-2 was significantly lower in cases with moderate–severe dysplasia both in cases with keratoacanthoma (SC keratoacanthoma-like, moderately differentiated/with severe atypia) (100.0 vs. 89.17 RFU/mg protein; p = 0.001) and in cases with Bowen’s disease (SCC in situ/high-grade SIL) (79.5 vs. 72.5 RFU/mg protein; p = 0.001) (Table 3, Figure 2). This evidence concerns the gene MMP2 and Bowen disease of the skin.