PRKN and Parkinson disease: Genetic models of PD, such as Parkin, PINK1 and DJ1, knock-in and knock-out models, viral overexpression models, α-synuclein protein propagation models and liposaccharide-induced models are also commonly found; however, in the present review, we included only environmental models: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), and rotenone, which lead to acute cell death with limited aggressive pathology, representing an advanced stage of the disease [46].