CHRNA7 and neuroblastoma: Physiological concentrations of Aβ1–42 evoked sustained increases in Ca2+ in isolated presynaptic nerve endings (synaptosomes) from rat brains, and in axonal varicosities of differentiated hybrid neuroblastoma NG108-15 cells, and this was largely inhibited in synaptosomal preparations from mice lacking the α7nAChR subunit or by application of α-BTX [125,139,140].