Boden et al. identified 38 proteins, including mitochondrial enzymes like superoxide dismutase 2, that were associated with the production or elimination of ROS and were upregulated in adipose tissue during overnutrition in men who consumed approximately 6000 kcal/day of a mixed diet (composed of around 50% carbohydrates, 35% fat, and 15% protein) [53]. This evidence concerns the gene SOD2 and overnutrition.