Based on the disruption of multicellular units (osteoblasts, osteoclasts, bone lining cells, and osteocytes) and the release of growth factors (TGF-B, FGF, PDGF, and IGF), the etiopathology of bone metastasis encourages the growth of tumor cells and compromises secondary bone architecture [52]. This evidence concerns the gene TGFB1 and neoplasm.