Mohr–Tranebjaerg syndrome (DYT-TIMM8A, OMIM#304700), an X-linked disease caused by disease-causing variants in TIMM8A, is a key example where deafness and dystonia are hallmark features accompanied by variable symptoms such as optic atrophy, pyramidal signs, psychiatric disturbances, and cognitive decline [181,182]. This evidence concerns the gene TIMM8A and optic atrophy.