A controlled intervention study utilizing the APPswe/PSEN1dE9 (APP/PS1) transgenic mouse model of Alzheimer’s disease demonstrated that chronic administration (16 weeks) of anthocyanin-enriched bilberry (Vaccinium myrtillus) and blackcurrant (Ribes nigrum) extracts (200 mg/kg/day, dietary supplementation) significantly reduced Aβ accumulation, and both extracts prevented cognitive decline and improved behavioral abnormalities [51]. This evidence concerns the gene APP and Alzheimer disease.