In LPS-stimulated RAW 264.7 cells, in addition to inhibiting iNOS/NO production, verbacoside, through activation of p38 and Nrf2 expression, induces heme oxygenase-1 (HO-1) which in turn reduces high mobility group box 1 (HMGB1) release in both macrophages and cecal ligation and puncture (CLP)-induced mouse sepsis model [203]. This evidence concerns the gene HMGB1 and Sepsis.