JUP and Sepsis: Therefore, future research should focus on (i) elucidating the molecular mechanisms underlying the observed effects; (ii) evaluating efficacy against clinically relevant, multidrug-resistant sepsis pathogens, such as Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa; (iii) determining the optimal dosing regimens and therapeutic windows for Pg when used in combination with different antibiotic classes.