Moreover, this co-localisation is enhanced when H3K27 demethylases, Ubiquitously Transcribed Tetratricopeptide Repeat X-linked protein (UTX) and Jumonate Domain-Containing 3 (JMJD3), are inhibited, further indicating the presence of H3K27me2 associated with the viral genome and its interaction with PHF20L1, which may have important implications for viral gene expression and infection processes. This evidence concerns the gene KDM6A and infection.