PHF20L1 directly inhibits a series of tumour suppressor factors, including Forkhead Box Protein K2 (FOXK2) and Hypermethylated in Cancer 1 (HIC1), through its synergistic action with the PRC2 and NuRD complexes, thereby driving glycolysis and promoting tumour occurrence [8]. The gene discussed is HIC1; the disease is neoplasm.