PFKFB3 and influenza: In addition, although the compound 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) has also been reported to attenuate influenza-related inflammation, its specificity as a PFKFB3 inhibitor is debated, suggesting that its observed effects may involve off-target mechanisms [339,340,341].