Studies have shown that in a mouse model of Pseudomonas aeruginosa-induced pneumonia, phagosomal and lysosomal depletion is accompanied by a decrease in Microtubule-associated protein 1A/1B-light chain 3-II (LC3-II) and Lysosome-associated membrane protein 1 (LAMP1) levels, along with enhanced Transcription Factor E3 (TFE3) binding, decreased TFEB, and elevated ZKSCAN3 expression, leading to suppression of autophagy and lysosomal gene transcription [114,125,126]. Here, TFE3 is linked to susceptibility to pneumonia measurement.