In conclusion, ZKSCAN3 is a key driver of gastric cancer progression through the integration of epigenetic regulation, activation of multiple signaling pathways, and microenvironmental remodeling, and the epigenetic and multipathway synergistic regulation model established by ZKSCAN3 in gastric cancer provides key clues for exploring its pan-cancer oncogenic mechanism. This evidence concerns the gene ZKSCAN3 and gastric cancer.