In vivo experiments further confirmed that MIA PaCa-2 cells silencing ZKSCAN3 formed larger tumor sizes in a nude mouse model, accompanied by up-regulation of LC3-II expression, elevation of the Ki-67 proliferation index, and enhancement of autophagic flow, suggesting that it promotes tumor growth by inhibiting autophagy [62,71,86]. Here, MKI67 is linked to neoplasm.