ZKSCAN3, as a multifaceted regulatory factor, is not only involved in the regulation of physiological functions of a wide range of normal cells, but also widely mediates the pathologic processes of various diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type 2 diabetes mellitus-related atherosclerosis (T2DM-AS), spinal bulbar muscular atrophy (SBMA), acute pancreatitis (AP), acute lung injury (ALI), and sepsis (Figure 4). The gene discussed is ZKSCAN3; the disease is atherosclerosis.