The large number and diversity of these neoantigens leads to the polyclonal clonal expansion of distinct T cells, each with a unique specificity, from which some dominant clones are selected and multiplied that exert a strong immune pressure on the tumor, secreting IFNγ and TNFα and releasing granzymes/perforin that induce the apoptosis of malignant cells [124]. The gene discussed is PRF1; the disease is neoplasm.