Similarly, in a recently published study using a murine model of allogeneic HCT, DF treatment improved survival and reduced clinical GvHD by exerting anti-inflammatory and endothelial protective effects, as evidenced by lower levels of TNFα, IL-6, VCAM-1, ICAM-1, and Ang-2 [112]. This evidence concerns the gene IL6 and graft versus host disease.