CXCL1 and Alzheimer disease: Aharon et al. demonstrated that plasma EVs isolated from AD patients show greater proportion of endothelial cells-derived EVs and elevated levels of myelin oligodendrocyte glycoprotein (MOG), as well as pro-inflammatory cytokines IFNγ, chemokine (C-C motif) ligand 5 (CCL5), and GRO (growth-regulated oncogene-alpha, CXCL1) compared to health controls [144].