In terms of prognosis, high levels of IL-6, IL-10, and B-cell-activating factor of the TNF family/B lymphocyte Stimulator (BAFF/BLyS) have been associated with poorer overall survival (OS) and progression-free survival (PFS) in HIV-NHL patients [59,60]. The gene discussed is TNFSF13B; the disease is non-Hodgkin lymphoma.