Jingda Li et al. [48] demonstrated in vivo and in vitro that hesperidin can upregulate antioxidants (SOD/GCLD/HO-1) by triggering the PI3K/AKT-Nrf2 pathway and reduce ROS overproduction and hepatotoxicity induced by OA, and the activation of NF-κB is known to improve oxidative stress in the liver through double verification in rat models of MASLD induced by HFD and HepG2 cells induced by oleic acid (OA). Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.