INSR and Insulin resistance: Sudha B Biddinger et al. [36] established a pure hepatic insulin resistance model in LIRKO mice (hepatic insulin receptor knockout mice) and found that the loss of insulin receptors in hepatocytes leads to a decrease in SREBP-1C, which regulates the expression of lipogenesis genes, and SREBP-2, which regulates the expression of cholesterol-producing enzymes and LDL receptors, affecting triglyceride accumulation.