Previous studies have demonstrated that inflammatory bowel disease (IBD) mice induced by a normal diet (NC) or a high-fat diet (HF) in combination with sodium dextran sulfate (DSS) treatment exhibit significant down-regulation of microsomal triglyceride transfer protein (MTP) and apolipoprotein B (ApoB) levels via the hepatocyte nuclear factor 4α (HNF4α) pathway. This evidence concerns the gene HNF4A and inflammatory bowel disease.