Fei Luo et al. [169] constructed a TM6SF2 (−/−) (TM6SF2 gene knockout) rat model by using gene editing technology CRISPR-Cas9 and found that TM6SF2 plays a role in ER and Golgi intermediate (ERGIC) and promotes large lipidization of ApoB-rich lipoproteins, thereby preventing the development of fatty liver disease. Here, TM6SF2 is linked to fatty liver disease.