The main effects observed following the use of RNase H1-activating ASOs targeting ncRNAs included suppression of tumor cell proliferation and migration, as well as induction of apoptosis in vitro [79,80,118,119,120,121,122,123,124,125] along with inhibition of tumor growth and metastasis in vivo [79,80,118,119,123,124,125]. The gene discussed is RNASEH1; the disease is neoplasm.