MDH2 and cerebellar ataxia: At the settings of q < 0.05 and a minimum of two genes per pathway, the shared DEPs belonged to 10 pathways (Krebs cycle, carbon metabolism, gap junction, morphine addiction, glutamatergic synapse, HIF-1 signaling, Fc γ R mediated phagocytosis (this process involves actin cytoskeleton), neutrophil extracellular trap formation, spinocerebellar ataxia, and parathyroid hormone synthesis secretion and action), with PRKCA and three enzymes belonging the Krebs cycle, CS, MDH2 and DLST, being the most common DEPs in these pathways (Figure 4E).