Nie et al. found that CAPE activated the phosphorylation of IRS-1 and Akt proteins, and simultaneously inhibited the phosphorylation and nuclear translocation of JNK and NK-κB p65 proteins in a type 2 diabetes mellitus (T2DM) model of C57BL/6J mouse [14]. This evidence concerns the gene MAPK8 and type 2 diabetes mellitus.