USP8 and familial dilated cardiomyopathy: Exogenous H2S supplementation in the form of sodium hydrosulfide (NaHS) prevents lipid deposits in cardiomyocytes by increasing the degradation of sterol regulatory element-binding protein 1 (SREBP1), inhibiting SREBP1 nuclear translocation [133], and regulating Parkin-dependent mitophagy by promoting the S-sulfhydration of ubiquitin-specific protease 8 (USP8) [134], thereby ameliorating DCM.