EPRS1 and Myocardial fibrosis: Elevated expression of glutamyl-prolyl-tRNA synthetase (EPRS), the sole enzyme in the mammalian cytoplasm responsible for catalyzing the synthesis of prolyl-tRNA, leads to increased formation of prolyl-tRNA, which directly enhances the translation of proline-rich extracellular matrix proteins, thereby promoting myocardial fibrosis under pathological conditions.