BECN1 and non-small cell lung carcinoma: reported that TRIM59 exerts dual functions in NSCLC by regulating BECN1-dependent autophagy through a dual mechanism: first, it inhibits the NFκB pathway to downregulate BECN1 transcription; secondly, it modulates the TRAF6-mediated K63-linked ubiquitination of BECN1, thereby influencing the assembly of the BECN1-PIK3C3 complex.