SQSTM1 and neoplasm: Zhang et al. demonstrated that the overexpression of Beclin 1 significantly inhibited the proliferation of esophageal cancer Eca109 cells and the growth of transplanted tumors in nude mice by activating autophagy, accompanied with increased LC3-II and decreased P62, confirming the tumor-suppressive effect of the Beclin 1-dependent autophagy pathway [125].