Taking the findings from pigs and mice (especially the Ang−/− model) together, we have demonstrated that (i) NLRP3 inflammasome is activated in porcine endometritis and LPS-induced murine endometritis; (ii) Ang deficiency exacerbates the activation of the NLRP3 inflammasome-related endometritis; (iii) Ang promotes the proliferation of epithelial cells, which contributes to the maintenance of endometrial health. Here, NLRP3 is linked to endometritis.