In addition, melatonin has been found to inhibit endoplasmic reticulum (ER) stress-mediated thioredoxin interacting protein (TXNIP)/NLRP3 inflammasome activation via adenosine monophosphate-activated protein kinase (AMPK) regulation in LPS-induced endometritis [25]. The gene discussed is NLRP3; the disease is endometritis.