Moreover, exosomes from the saliva of patients with oral SCC promoted tumor growth via the activation of phosphatidylinositol 3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), and c-Jun-1 N-terminal kinase/signal transducer and activator of transcription (STAT)-2 pathways [141]. Here, AKT1 is linked to neoplasm.