Also, Madeo et al. indicated that EphrinB1-containing exosomes released from the tumor could promote tumor innervation and tumor cell dissemination by inducing axonogenesis [152], and Mutschelknaus et al. [153] found that EVs derived from irradiated HNSCC cells could modify tumor cell motility and promote tumor cell migration via AKT signaling. This evidence concerns the gene AKT1 and neoplasm.