IRF8 and lip and oral cavity carcinoma: Furthermore, the researchers also identified 45 hypermethylated promoters shared by PMOD and oral cancer in known tumor suppressor genes: CDKN1B (cyclin-dependent kinase inhibitor 1B (p27KIP1), ZFP82 (ZFP82 zinc finger protein), SHISA3, (Shisa family member 3), GPX7 (glutathione peroxidase 7), and IRF8 (interferon regulatory factor 8).