For instance, proteomic analysis found that exosomal proteins MUC5B, HPA, LGALS3BP, A2M, IGHA1, GAPDH, and PKM1/M2 were clearly differentiated in patients with oral cancer compared to healthy individuals; their presence in EVs allowed OSCC to be distinguished from controls with 90% accuracy, indicating that they may represent a promising diagnostic and prognostic biomarker [138]. This evidence concerns the gene LGALS3BP and lip and oral cavity carcinoma.