KIF1A and EDNRB were methylated in 38% and 67.6% of salivary rinses from HNSCC patients, respectively, vs. in 2% and 6.6% of normal salivary rinses (p < 0.0001)↑ Higher levels of methylated salivary rinse samples from HNSCC patients having stage I and II, but not for stage III and IV. This evidence concerns the gene KIF1A and head and neck squamous cell carcinoma.