1679 genes exhibited different expression levels in saliva between OSCC and controls (p < 0.05)↑ Higher expression of seven cancer-related mRNA transcripts, i.e., IL8, IL-1β, DUSP1, H3F3A, OAZ1, S100P, and SAT in OSCC vs. HC—a 3.5-fold elevation in OSCC saliva (p < 0.01). This evidence concerns the gene IL1B and cancer.