The most important genes that undergo hypermethylation include RASSF1A (Ras association domain-containing protein 1, RASSF2A (Ras association domain-containing protein 2), MGMT (methylated-DNA-protein-cysteine methyltransferase), DAPK (death-associated protein kinase 1), and FHIT (bis 5′-adenosyl-triphosphatase, also known as fragile histidine triad protein); as these are characteristic of the early stages of OSCC development, they can be considered potential early diagnostic markers of cancer [62]. The gene discussed is MGMT; the disease is cancer.