However, this study emphasizes CYP4B1, CYP4F12, and CYP4F3 gene expression levels, focusing on the tumor and normal tissue analysis; their expression, adjusted in stages; their correlation with BRCA1, BRCA2, and ESR1; the estrogen receptor status; and the overall survival analysis in breast cancer patients, while also exploring their expression profiles and alterations across other organs and cancer types. This evidence concerns the gene ESR1 and breast carcinoma.