An analysis of the available literature, data mining, and hub gene scoring led to the identification of a molecular panel of 16 genes as a discrimination index between cancer tissue and control tissue: PSMD14, STC2, PDE4D, AURKA, LAMC2, CEP55, RELB, ICAM1, STIP1, DTL, TTK, ALG1L, TDO2, ADGRE2, CKAP2, and SERPINE1. This evidence concerns the gene SERPINE1 and cancer.