Given the critical role and frequent abnormal activation of the PI3K-AKT-mTOR and MAPK/ERK signaling pathways in tumors, we speculate that PAQR3 may regulate the growth of colon cancer cells by inhibiting the PI3K-AKT-mTOR pathway, the MAPK/ERK pathway, or even the Wnt pathway [39]. Here, PIK3CA is linked to malignant colon neoplasm.