A recent study highlighted the pro-oncogenic role of the aldehyde dehydrogenase 3 family member B2 (ALDH3B2) enzyme in the three subgroups of CCA through the molecular axis ALDH3B2–integrin β1 (ITGB1)–ERK1/2 [68]. The gene discussed is ITGB1; the disease is cholangiocarcinoma.