On the contrary, circPCNXL2 (hsa_circ_0016956) is overexpressed in iCCA and promotes tumor cell proliferation and metastasis by interacting with serine-threonine kinase receptor-associated protein (STRAP) and, consequently, facilitating the activation of MEK1/2-ERK1/2. This evidence concerns the gene MAP2K1 and infantile convulsions and choreoathetosis.