VEGFA and neoplasm: In the neoplasm, the pro-angiogenic factors, such as VEGF (vascular endothelial growth factor), FGF (fibroblast growth factor), PDGF (platelet-derived growth factor), TGFβ (transforming growth factor β) and TNF (tumour necrosis factor), secreted by endothelial cells and neoplastic cells, begin to predominate [15].