Notably, PROS1 ligand and SDC3/PLXNB2 receptors showed significant correlation with poor prognosis, potentially explaining why cancer_macro 1 represents the core immunosuppressive subpopulation in cancer zone B. Previous studies indicate that the PROS1-AXL axis fosters an immunosuppressive environment by downregulating MHC I–mediated antigen presentation and inhibiting NKG2D signaling [42,43,44]. This evidence concerns the gene SDC3 and cancer.