In cancer zone B, the SEMA4 pathway relied on Sema4a-Plxnb2, Sema4d-Cd72, and Sema4d-Plxnb2 interactions, with Sema4a/d-Plxnb2 showing particularly strong communication between cancer_macro 1 cells (Figure 4E). This evidence concerns the gene SEMA4A and cancer.