Research has shown that CREPT knockdown using Adeno-associated viruses (AAV) delivery and targeting via microRNAs, including mir-449-5P, microRNA-501–3p, microRNA-449b-5p, and microRNA-383, has suppressed its expression and interrupted the aberrant Wnt signaling, which leads to the suppression of tumor growth [7,11,17,18,27]. Here, RPRD1B is linked to neoplasm.