Serum REG3A < 17.5 μg/L links to cancer (n = 254) [48], high TNM grade (n = 58) [77] and poor survival [48,77]REG3A localizes to peritumoral acini and CK19+ preneoplastic lesions [48,77,79]REG3A correlates with IL6/JAK/STAT3 in peritumoral acini [77]. This evidence concerns the gene STAT3 and cancer.