REG3A localizes to cirrhotic hepatocytes [26,27,58]REG3A links to low stage HCC, no vascular invasion, β-catenin mutation (n = 265) [73]REG3A associates with β-catenin activation (42 NT/T) [60]REG3A improves disease-free survival in cirrhosis (n = 216) [20]No link between REG3A and OS in patients with HCC (n = 507) [20]. The gene discussed is REG3A; the disease is hepatocellular carcinoma.