REG3A promotes cancer in DMBA-caerulein and Pdx1-Cre; KrasG12D; Ink4a/Arffl/fl models [48,76,79,80]REG3A enhances tumor growth and induces immunosuppression in Panc02 xenografts [78]REG3A activates EGFR/JAK2/STAT3 and synergizes with IL6 to boost tumors in xenograft mice [75,78]. Here, PDX1 is linked to cancer.