Using a referral biobank of 562 patients—including 120 healthy control participants, 277 with at risk chronic liver disease (CLD) and 165 patients with HCC—we compared the diagnostic performance of several models, including GALAD, GAAP, ASAP, Doylestown and aMAP, with biomarkers alone, including Alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3) and des-gamma-carboxy prothrombin (DCP). Here, AFP is linked to hepatocellular carcinoma.